ESPE Abstracts

ESPE Abstracts

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hrp0095t2 | Section | ESPE2022

Conditional PTEN knockout in mouse osteoprogenitor cells impacts bone structure and turnover

Lorenz Judith , Kirstein Anna , Nebe Michѐle , Richter Sandy , LeDuc Diana , Kiess Wieland , Klöting-Blüher Nora , Baschant Ulrike , Garten Antje

Background: Bone development and remodeling are controlled by the phosphoinositid-3-kinase (PI3K) signaling pathway. We investigated the effects of downregulation of phosphatase and tensin homolog (Pten), a negative regulator of PI3K signaling, in osteoprogenitor cells.Methods: Femura, tibiae and bone marrow stromal cells (BMSCs) from mice with Cre-inducible Pten knockdown in cells expressing the transcription factor Ost...
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hrp0094p2-73 | Bone, growth plate and mineral metabolism | ESPE2021

PTEN downregulation in mouse osteoprogenitor cells impacts on bone stability and turnover

Lorenz Judith , Kirstein Anna , Nebe Michѐle , Richter Sandy , Le Duc Diana , Kiess Wieland , Kloting-Bluher Nora , Baschant Ulrike , Garten Antje ,

Background: Signaling through the phosphoinositid-3-kinase (PI3K) pathway modulates bone development and remodeling. We aimed to dissect the role of phosphatase and tensin homolog (Pten), a negative regulator of PI3K signaling, in osteoprogenitor cells.Methods: Femura, tibiae and bone marrow stromal cells (BMSCs) from mice with Cre-inducible Pten knockdown in cells expressing the transcription factor Osterix (Pten cKO) a...
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ESPE Abstracts

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